Mike,
From your link: Last Updated: February 11, 2021
Ivermectin is not approved by the FDA for the treatment of any viral infection.
Recommendation
There is insufficient evidence for the COVID-19 Treatment Guidelines Panel (the Panel) to recommend either for or against the use of ivermectin for the treatment of COVID-19. Results from adequately powered, well-designed, and well-conducted clinical trials are needed to provide more specific, evidence-based guidance on the role of ivermectin in the treatment of COVID-19.
I like to look for quality of truth and accuracy in a range of distributed information. I see where about 1/3 of the countries in the world are effectively using Ivermectin as a prophylactic and early infection treatment with zinc and antibiotics with good results in reducing death from Covid-19. Inexpicably, there is opposition and a lack of promotion for early therapeutic treatments in the US before hospitalization is required. Unfortunately, this has resulted in far too much censorship and purposeful misinformation put out by government bureaucrats and MSM that can only see yesterdayâs science and agendas. There really is a rabbit hole and a great divide in this country that needs to be revealed and healed. Cancel culture and ignorance has cost the country far too much. Is vaccination the universal answer for everyone in reducing deaths from this disease?
I agree we are all at risk, but itâs a relative risk that must be weighed on an individual basis. I can support vaccination while opposing forced vaccination by mandate. Vaccination for diseases such as smallpox with a mortality rate of 30% or Polio with a mortality rate of 23% are easily accepted and warranted. Public health policy that fails to consider the effectiveness of natural immunity will fail to meet its goal of public safety. Covid-19 has a mortality rate of about 1% overall, much higher in the elderly and those with comorbidities, with 80% of deaths occurring in those over 65 years of age. In those under 18, the average mortality rate over the past 3 years for seasonal flu is greater than that for Covid-19 (source CDC). The occurrence needing hospitalization is so low that vaccination does not warrant the mandating of vaccination in this young age group. Coercing a vaccine on a population without considering all the science and updating its data and policies does not govern wisely. The link you provided was last updated in early February. Much progress has occurred since that time. There are actually many studies supporting the safe use of Ivermectin. The FDA/CDC/NIH have put a low priority on conducting gold standard research to support itâs use
Why?
Ivermectin for COVID-19: real-time meta analysis of 64 studies
Covid Analysis, Oct 21, 2021, Version 136
â˘Meta analysis using the most serious outcome reported shows 67% [53â76%] and 86% [75â92%] improvement for early treatment and prophylaxis, with similar results after exclusion based sensitivity analysis (which excludes all of the GMK/BBC team studies), with primary outcomes, and after restriction to peer-reviewed studies orRandomized Controlled Trials.
â˘Statistically significant improvements are seen for mortality, ventilation, ICU admission, hospitalization, recovery, cases, and viral clearance. 31 studies show statistically significant improvements in isolation.
â˘Results are very robust â in worst case exclusion sensitivity analysis 53 of 64 studies must be excluded to avoid finding statistically significant efficacy.
â˘While many treatments have some level of efficacy, they do not replace vaccines and other measures to avoid infection. Only 25% of ivermectin studies show zero events in the treatment arm.
â˘Multiple treatments are typically used in combination, and other treatments could be more effective, including monoclonal antibodies which may be available in countries not recommending ivermectin (sotrovimab, casirivimab/imdevimab, andbamlanivimab/etesevimab).
â˘Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all variants. All practical, effective, and safe means should be used, including treatments, as supported by Pfizer [Pfizer, TrialSiteNews] . Denying the efficacy of treatments increases the risk of COVID-19 becoming endemic; and increases mortality, morbidity, and collateral damage.
â˘There is evidence of a negative publication bias, and the probability that an ineffective treatment generated results as positive as the 64 studies is estimated to be 1 in 222 billion.
â˘Over 20 countries have adopted ivermectin for COVID-19. The evidence base is much larger and has much lower conflict of interest than typically used to approve drugs.
â˘All data to reproduce this paper and sources are in the appendix. See [Bryant, Hariyanto, Kory, Lawrie, Nardelli] for other meta analyses with similar results confirming efficacy.
â˘There is evidence of a negative publication bias, and the probability that an ineffective treatment generated results as positive as the 64 studies is estimated to be 1 in 222 billion.
â˘Over 20 countries have adopted ivermectin for COVID-19. The evidence base is much larger and has much lower conflict of interest than typically used to approve drugs.
â˘All data to reproduce this paper and sources are in the appendix. See [Bryant, Hariyanto, Kory, Lawrie, Nardelli] for other meta analyses with similar results confirming efficacy.
https://ivmmeta.com
There is much more on this one site validating the efficacy of using Ivermectin (and other sites if one has a discerning eye for facts) that is constantly updated. FDAâs âTreatment Guidelines Panelâ is not staying informed of the facts or just chooses to ignore them. Many researchers have been forced into pre-publication because Journals tend to only support those large Pharmaceuticals that advertise and support publication in their journals. The CDC and FDA have bungled far too much and ignored legitimate data being used elsewhere throughout the globe. Why?
A return to common sense based on science would yield far more success in winning the fight to reduce deaths caused by Covid-19. Restore economic health without resorting to forced mandates. If this disease had the same mortality rates as Smallpox (30%) and Polio (approx. 23% - CDC) people would not be hesitating to receive the vaccine.